| Expression pattern: |
DN |
| Associated gene: |
FRK, AGO2 |
| Associated microRNA: |
miR-135b-5p |
| Biological function: |
inhibits osteosarcoma cell proliferation, invasion, and migration; suppresses tumor growth and lung metastasis |
| Molecular mechanism: |
ceRNA mechanism: circYAP1 sponges miR-135b-5p to relieve repression of FRK |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; ISH (In Situ Hybridization); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circYAP1 expression is associated with higher metastasis rate, more advanced clinical stage, and shorter overall survival time in osteosarcoma patients |
| Description: |
circYAP1 is down-regulated in osteosarcoma and acts as a tumor suppressor by inhibiting proliferation, invasion, migration, and lung metastasis. Mechanistically, it functions as a ceRNA that sponges miR-135b-5p to upregulate the tumor-suppressor FRK. Low circYAP1 expression is associated with metastatic status, advanced clinical stage, and worse overall survival. |
| Confidence score: |
0.8107 |