circRNA basic information
circBase ID: -
Name: mmu_circ_Hipk3
Synonym: circRNA Hipk3 / circHipk3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005203
MONDO name: ischemia reperfusion injury
Disease details: renal ischemia reperfusion injury / renal IRI
Disease DO ID:
 -
Disease MeSH ID:
 D015427
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

kidneys / kidney tissues
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: GDF15
Associated microRNA: miR-30, miR-1, miR-181, miR-23, miR-383
Biological function: unknown
Molecular mechanism: GDF15 modulates circHipk3 expression during renal IRI; a circRNA-miRNA-gene regulatory network was computationally constructed but not experimentally validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

In mouse renal ischemia-reperfusion injury, circHipk3 is down-regulated in injured kidneys and its decrease is attenuated by GDF15 overexpression. The study provides RT-qPCR evidence for differential expression and a predicted circHipk3-miRNA-gene network without functional validation.
Confidence score:

0.31
Other information
Title:

Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.

Journal: Frontiers in cell and developmental biology
Published: 2025
PubMed ID: 40673270
Study type:

biological research
Data availability: All data in this study are available upon reasonable request.
Code availability: -