| Expression pattern: |
UP |
| Associated gene: |
RIMS1 |
| Associated microRNA: |
hsa-miR-338-3p |
| Biological function: |
Potential biomarker for ovarian cancer detection; expression positively correlates with ovarian cancer development and stage. |
| Molecular mechanism: |
Predicted ceRNA mechanism via hsa-miR-338-3p regulating hub gene RIMS1. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); ErbB (other); Wnt/beta-catenin (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
circRNA-seq; RNase R Treatment; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis; Microarray |
| Clinical significance: |
Diagnostic biomarker candidate; shows high AUC in ROC analysis and included in CMD panel for early OC detection. |
| Description: |
hsa_circ_0007440 (host gene CTNNA1) is up-regulated in ovarian cancer across tissue and plasma validations and is included in a CMD diagnostic panel with strong ROC performance. It participates in predicted ceRNA axes, notably hsa_circ_0007440-hsa-miR-338-3p-RIMS1. |
| Confidence score: |
0.6841 |