| Expression pattern: |
UP |
| Associated gene: |
MUC16 |
| Associated microRNA: |
hsa-miR-330-5p |
| Biological function: |
Potential biomarker for ovarian cancer detection; expression positively correlates with ovarian cancer development and stage. |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network (circRNA-miRNA-hub gene axes). |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); ErbB (other); Wnt/beta-catenin (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Diagnostic biomarker candidate; shows high AUC in ROC analysis and included in CMD panel for early OC detection. |
| Description: |
hsa_circ_0049101 (host gene MUC16) is up-regulated in ovarian cancer and increases with clinical stage in patient plasma. It is part of a multi-marker CMD panel and shows strong diagnostic performance by ROC analysis; mechanistically it was included in predicted circRNA-miRNA-mRNA (ceRNA) networks (e.g., with hsa-miR-330-5p). |
| Confidence score: |
0.6548 |