| Expression pattern: |
UP |
| Associated gene: |
HK2 |
| Associated microRNA: |
miR-488 |
| Biological function: |
Circ_0008928 promotes cisplatin resistance, cell proliferation, migration, invasion, and glycolysis metabolism in CDDP-resistant NSCLC; circ_0008928 knockdown improves CDDP sensitivity and suppresses these malignant phenotypes. |
| Molecular mechanism: |
Circ_0008928 acts as a ceRNA sponge for miR-488 to upregulate HK2 expression, thereby regulating CDDP resistance, tumor progression, and glycolysis metabolism. |
| Biological pathway or process: |
ceRNA regulation (promotes); chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; CCK8; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Exosome-based circ_0008928 may serve as a potential biomarker for the diagnosis of NSCLC and is increased in serum exosomes of CDDP-resistant NSCLC patients. |
| Description: |
Circ_0008928 is upregulated in NSCLC cells, CDDP-resistant NSCLC cells, and serum exosomes from CDDP-resistant NSCLC patients. It promotes cisplatin resistance, proliferation, migration, invasion, and glycolysis by sponging miR-488 and increasing HK2 expression, while knockdown restores CDDP sensitivity and suppresses malignant phenotypes. Serum exosomal circ_0008928 is proposed as a potential diagnostic biomarker for NSCLC. |
| Confidence score: |
0.7283 |