| Expression pattern: |
UP |
| Associated gene: |
FGFR2 |
| Associated microRNA: |
miR-223, miR-507, miR-508, miR-653 |
| Biological function: |
promotes bladder cancer cell proliferation and migration/metastasis; silencing suppresses tumor growth and metastasis |
| Molecular mechanism: |
circUVRAG acts as a miRNA sponge for miR-223, thereby relieving miR-223-mediated suppression of FGFR2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
may provide a potential biomarker and therapeutic target for the management of BLCA; potential biomarker for the prognosis of BLCA |
| Description: |
circUVRAG is up-regulated in bladder cancer cell lines and mainly localized in the cytoplasm. circUVRAG promotes proliferation and migration/metastasis by sponging miR-223, thereby increasing FGFR2 expression; silencing circUVRAG suppresses tumor growth and metastasis in vitro and in a nude mouse xenograft model. |
| Confidence score: |
0.5997 |