| Expression pattern: |
UP |
| Associated gene: |
TRIM14, AGO2 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
promotes proliferation and migration and inhibits apoptosis during OLK malignant transformation/carcinogenesis |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge to sequester miR-195-5p and relieve its inhibition on TRIM14; associated with AGO2-containing RISC |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay |
| Clinical significance: |
potential diagnostic biomarker with high diagnostic sensitivity and specificity (ROC/AUC) in carcinogenesis progression of normal mucosa and OLK toward OSCC |
| Description: |
hsa_circ_0060927 is upregulated across NOM→OLK→OSCC and promotes malignant transformation-related phenotypes. It localizes mainly in the cytoplasm and functions as a ceRNA by binding miR-195-5p (via AGO2/RISC), thereby relieving miR-195-5p suppression of TRIM14 and enhancing proliferation and migration while inhibiting apoptosis in LEUK1 cells; it also shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.8748 |