circRNA basic information
circBase ID: hsa_circ_0072088
Name: hsa_circ_ZFR
Synonym: circRNA ZFR / circ-0072088
Host Gene: ZFR
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; whole blood; HCC tissues; adjacent normal tissues; liver tissues
Cell lines:

HepG2; Bel-7402; SMMC-7721; Hep3B; Huh-7; QSG-7701; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC1A1
Associated microRNA: miR-96a-5p
Biological function: promotes proliferation, migration, invasion, tumor growth and metastasis in HCC; knockdown inhibits HCC progression
Molecular mechanism: circZFR acts as a ceRNA sponge for miR-96a-5p to modulate SLC1A1 expression; also reported binding/enrichment at SLC1A1 promoter region
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); other pathway/process (unclear)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

CircRNA ZFR was elevated in plasma and tissues of HCC patients and associated with tumor differentiation, tumor size and TNM stage
Description:

circRNA ZFR (circZFR; hsa-circ_0072088) is up-regulated in HCC plasma/blood, tumor tissues, and HCC cell lines. Functionally, circZFR promotes HCC proliferation, migration, invasion and in vivo tumor progression, mainly by sponging miR-96a-5p and relieving repression of SLC1A1, forming the circZFR/miR-96a-5p/SLC1A1 axis.
Confidence score:

0.7375
Other information
Title:

CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma.

Journal: Scientific reports
Published: 2025
PubMed ID: 40664766
Study type:

combined biological and clinical study
Data availability: 10.1038/s41598-025-07974-8
Code availability: -