| Expression pattern: |
DN |
| Associated gene: |
GATA6, SHISA6 |
| Associated microRNA: |
miR-944, miR-1270 |
| Biological function: |
May affect PSCC progression through a circRNA-miRNA-mRNA ceRNA network. |
| Molecular mechanism: |
Predicted ceRNA mechanism: circ_CDR1as may sponge miR-944 (and miR-1270), thereby relieving miRNA-mediated inhibition of GATA6; miR-944 involvement is prediction/correlation without direct experimental evidence. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic targets for PSCC patients (circ_CDR1as and GATA6). |
| Description: |
circ_CDR1as is significantly down-regulated in PSCC tissues and is proposed to act via a ceRNA network. The study predicts that circ_CDR1as may sponge miR-944/miR-1270 and thereby modulate downstream targets, with GATA6 showing consistent down-regulation and positive correlation with circ_CDR1as. |
| Confidence score: |
0.4685 |