| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with tumor progression, including TNM stage, tumor size, and lymph metastasis; potential diagnostic and prognostic biomarker for CRC. |
| Molecular mechanism: |
Not experimentally determined; abnormal circ_PVT1 might regulate CRC progression. |
| Biological pathway or process: |
metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
Potential diagnostic and prognostic marker for CRC; correlated with TNM stage, tumor size, lymph node metastasis, ROC AUC 0.8389, and poor prognosis with higher expression. |
| Description: |
circ_PVT1 was significantly up-regulated in serum/plasma from CRC patients compared with healthy controls. Its higher expression was associated with TNM stage, tumor size, lymph metastasis, diagnostic ROC performance, and unfavorable survival, supporting its role as a potential CRC diagnostic and prognostic biomarker. |
| Confidence score: |
0.4992 |