| Expression pattern: |
UP |
| Associated gene: |
ROCK1 |
| Associated microRNA: |
miR-335-5p |
| Biological function: |
promotes HCC cell growth/proliferation and migration |
| Molecular mechanism: |
ceRNA sponge of miR-335-5p to upregulate ROCK1 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
High circ_0064288 expression was associated with shorter overall survival time of the HCC patients; higher expression of circ_0064288 was associated with larger tumor size |
| Description: |
circ_0064288 is up-regulated in hepatocellular carcinoma and promotes proliferation and migration. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-335-5p, thereby increasing ROCK1 expression. High circ_0064288 expression is associated with shorter overall survival in HCC patients. |
| Confidence score: |
0.7474 |