| Expression pattern: |
UP |
| Associated gene: |
PAX3 |
| Associated microRNA: |
miR-217 |
| Biological function: |
Promotes osteosarcoma progression by enhancing proliferation, migration and invasion, facilitating tumor growth, and inhibiting apoptosis; associated with EMT changes (decreases E-cadherin and increases Vimentin). |
| Molecular mechanism: |
Acts as a competing endogenous RNA (miRNA sponge) for miR-217, thereby positively regulating PAX3 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circANKIB1 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes OS cell proliferation, migration/invasion, EMT and tumor growth by sponging miR-217 to relieve repression of PAX3 (circANKIB1/miR-217/PAX3 ceRNA axis). |
| Confidence score: |
0.7597 |