circRNA basic information
circBase ID: hsa_circ_0064644
Name: hsa_circ_RBMS3
Synonym: -
Host Gene: RBMS3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone metastasis tissues; non-bone metastasis tissues; breast cancer bone metastases; primary lesion tissues
Cell lines:

MCF-10A; MCF-7; MDA-MB-231; RAW 264.7; 1833; 231-BM6; LM2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT1, CDKN1A, PDPK1, SUMO1, ETS1, PRKCD, ACTN4, H2AZ1, RPF2, SDC3
Associated microRNA: miR-654-3p
Biological function: CircRBMS3 promotes breast cancer cell proliferation, migration, invasion, bone resorption gene expression, osteoclast phenotype gene expression, and bone metastasis-associated processes; circRBMS3 knockdown represses these malignant phenotypes.
Molecular mechanism: CircRBMS3 acts through a ceRNA mechanism by binding miR-654-3p and regulating downstream mRNAs, especially a potential circRBMS3-miR-654-3p-Akt1 axis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

CircRBMS3 is upregulated in bone metastasis breast cancer tissues and high circRBMS3 expression is associated with poor 3-year overall survival; it might be a potential prognostic marker.
Description:

CircRBMS3 is upregulated in bone metastasis breast cancer and high expression is associated with shorter 3-year overall survival. Functionally, circRBMS3 promotes breast cancer cell proliferation, migration, invasion, and bone metastasis-related osteoclast/bone resorption gene expression. Mechanistically, the study proposes a circRBMS3-miR-654-3p-mRNA ceRNA network, with AKT1 highlighted as a potential downstream hub.
Confidence score:

0.7513
Other information
Title:

To investigate the role and potential mechanism of has_circ_RBMS3 in bone metastasis of breast cancer based on bioinformatics.

Journal: Cell biochemistry and biophysics
Published: 2024
PubMed ID: 38822975
Study type:

combined biological and clinical study
Data availability: GSE111504; GSE101123; TCGA-BRCA; Supplementary Table 1; https://doi.org/10.1007/s12013-024-01332-7
Code availability: -