| Expression pattern: |
UP |
| Associated gene: |
MYC |
| Associated microRNA: |
let-7c |
| Biological function: |
promotes prostate cancer cell proliferation/tumor growth |
| Molecular mechanism: |
Potential miRNA sponge relationship involving let-7c; circPVT1 knockdown upregulates let-7c without reducing MYC protein in this study |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
ISH (In Situ Hybridization); RT-qPCR; Clinical Sample Validation; Transfection; Western Blot |
| Clinical significance: |
Higher circPVT1 positivity/expression is associated with higher Grade Group (GG2-5 vs GG1), suggesting utility as a marker of malignancy and a therapeutic target in more malignant prostate cancers |
| Description: |
circPVT1 is more frequently expressed in higher-grade prostate cancer (GG2-5 vs GG1) and localizes to the cytoplasm in tumor cells. Specific knockdown of circPVT1 (CRISPR/RfxCas13d) reduces PC-3 cell numbers, supporting a pro-proliferative role and potential therapeutic target; let-7c is upregulated after knockdown, suggesting a possible circPVT1-miRNA interaction. |
| Confidence score: |
0.5297 |