| Expression pattern: |
UP |
| Associated gene: |
SP1 |
| Associated microRNA: |
miR-2467-3p |
| Biological function: |
promotes proliferation; inhibits apoptosis; promotes migration; promotes invasion |
| Molecular mechanism: |
circNINL acts as a miRNA sponge for miR-2467-3p and thereby regulates SP1 expression (ceRNA mechanism). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
circNINL expression correlates with tumor size, differentiation, interstitial infiltration, vascular invasion, FIGO stage and lymph node metastasis. |
| Description: |
circNINL is up-regulated in cervical cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion and reduced apoptosis) by sponging miR-2467-3p to upregulate SP1, forming a circNINL/miR-2467-3p/SP1 ceRNA axis. |
| Confidence score: |
0.8122 |