circRNA basic information
circBase ID: hsa_circ_0007608
Name: hsa_circ_ASH1L
Synonym: -
Host Gene: ASH1L
Genomic location(hg19): chr1:155340294-155340774:-
Genomic location(hg38): chr1:155370503-155370983:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005149
MONDO name: pulmonary hypertension
Disease details: pulmonary hypertension in COPD / COPD-PH
Disease DO ID:
 6432
Disease MeSH ID:
 D006976
Disease NCIt ID:
 -
Disease ICD11 ID:
 1496633964
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung tissues; serum
Cell lines:

HPAECs; HPASMCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: VCAM1, VCAN, THBS1
Associated microRNA: -
Biological function: May be involved in the pathogenesis of COPD-PH and related to cellular proliferation, migration and EndMT.
Molecular mechanism: Potential ceRNA mechanism via predicted circRNA-miRNA-mRNA regulatory network.
Biological pathway or process:

proliferation (other); migration (other); EMT (other); NF-kappaB (other); TGF-beta/SMAD (other); MAPK (other); inflammation (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Potential biomarkers for COPD-PH.
Description:

hsa_circ_0007608 is up-regulated in COPD-PH (validated by qRT-PCR) and is highlighted as a potential biomarker/marker. The study proposes it may act via a predicted circRNA-miRNA-mRNA (ceRNA) network and be related to proliferation, migration and EndMT, with enrichment in pathways including NF-kappaB, TGF-beta, MAPK and TNF signaling.
Confidence score:

0.4032
Other information
Title:

Expression Profiles of circRNAs and Identification of hsa_circ_0007608 and hsa_circ_0064656 as Potential Biomarkers for COPD-PH Patients.

Journal: International journal of chronic obstructive pulmonary disease
Published: 2023
PubMed ID: 37955024
Study type:

combined biological and clinical study
Data availability: PRJNA913650
Code availability: -