circRNA basic information
circBase ID: hsa_circ_0001806
Name: hsa_circ_CSPP1
Synonym: circCSPP1
Host Gene: CSPP1
Genomic location(hg19): chr8:68018139-68028357:+
Genomic location(hg38): chr8:67105904-67116122:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; normal mammary tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for breast cancer; higher expression in ER-negative, PR-negative, HER2-negative and TNBC subgroups.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circCSPP1 showed strong diagnostic potential for BC (AUC 0.95; sensitivity 0.95; specificity 0.97).
Description:

circCSPP1 (hsa_circ_0001806) is significantly up-regulated in breast cancer tumor tissues versus adjacent normal tissues, with higher expression in ER-/PR-/HER2- and TNBC subgroups. It shows strong diagnostic performance in BC based on ROC analysis.
Confidence score:

0.6238
Other information
Title:

Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers.

Journal: Iranian biomedical journal
Published: 2025
PubMed ID: 40629030
Study type:

clinical study
Data availability: GSE101124
Code availability: -