| Expression pattern: |
UP |
| Associated gene: |
PLEKHG4B, ESRP1 |
| Associated microRNA: |
miR-661 |
| Biological function: |
promotes HCC cell viability, migration, EMT and metastasis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_0008043 sponges miR-661 to regulate PLEKHG4B; ESRP1 promotes circ_0008043 biogenesis |
| Biological pathway or process: |
migration (promotes); EMT (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ_0008043 expression is associated with AFP levels, tumor size, tumor differentiation, distant metastasis, and poorer overall survival in HCC patients |
| Description: |
circ_0008043 (circPTGR1), derived from PTGR1 exons 5-9, is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC cell viability, migration/EMT and lung metastasis by acting as a ceRNA sponge for miR-661, thereby relieving miR-661-mediated repression of PLEKHG4B; ESRP1 enhances circ_0008043 biogenesis. |
| Confidence score: |
0.8584 |