| Expression pattern: |
UP |
| Associated gene: |
CBFB |
| Associated microRNA: |
- |
| Biological function: |
CircRIP2 promotes CRC proliferation, migration, tumor growth and deterioration; circRIP2 knockdown weakens proliferative and migratory abilities and slows CRC growth in nude mice. |
| Molecular mechanism: |
CircRIP2 directly binds CBFB and aggravates malignant progression of CRC by negatively regulating CBFB through the circRIP2/CBFB axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
High level of circRIP2 predicted advanced staging and high risk of distant metastasis of CRC; circRIP2 is a potential indicator for predicting tumor staging and distant metastasis of CRC. |
| Description: |
CircRIP2 is upregulated in CRC tissues and cell lines and is associated with advanced T stage and distant metastasis. Functionally, circRIP2 promotes CRC cell proliferation, migration and xenograft tumor growth. Mechanistically, it aggravates CRC deterioration through negative regulation of CBFB via a circRIP2/CBFB axis. |
| Confidence score: |
0.7113 |