| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; associated with aggressive clinicopathological characteristics and poor prognosis |
| Molecular mechanism: |
ceRNA mechanism / miRNA sponge (predicted) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
can act as a novel noninvasive biomarker for the diagnosis and prognosis of GC; expression level is closely associated with TNM stage; an independent prognostic factor |
| Description: |
This study shows that hsa_circ_0000467 is significantly upregulated in gastric cancer tissues, plasma, and cell lines. It promotes GC cell proliferation, migration, and invasion while inhibiting apoptosis, and its high expression is associated with advanced stage and poor prognosis. The circRNA may serve as a noninvasive diagnostic and prognostic biomarker and a potential therapeutic target in gastric cancer. |
| Confidence score: |
0.7888 |