| Expression pattern: |
UP |
| Associated gene: |
HMGB3 |
| Associated microRNA: |
miR-145-5p, miR-338-3p |
| Biological function: |
circ_PSD3 promotes PTC cell proliferation, migration, invasion and EMT; circ_PSD3 knockdown suppresses proliferation, migration and invasion. |
| Molecular mechanism: |
circ_PSD3 acts as a ceRNA sponge for miR-145-5p and miR-338-3p, thereby regulating HMGB3 expression and promoting malignant behavior and EMT in PTC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_PSD3 expression was associated with lymph node metastasis, TNM stage and tumor volume, and may be a potential therapeutic target for PTC. |
| Description: |
circ_PSD3 is up-regulated in papillary thyroid carcinoma tissues and cells and functions as an oncogenic circRNA. It promotes PTC cell proliferation, migration, invasion and EMT by sponging miR-145-5p and miR-338-3p, thereby enhancing HMGB3 expression. Its expression is associated with lymph node metastasis, TNM stage and tumor volume, suggesting potential clinical relevance. |
| Confidence score: |
0.7129 |