circRNA basic information
circBase ID: hsa_circ_0000994
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: SLC8A1
Genomic location(hg19): chr2:40655612-40657444:-
Genomic location(hg38): chr2:40428472-40430304:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

quadriceps; spinal cord
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

oxidative stress (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

circSLC8A1 is decreased in ALS quadriceps at symptomatic and terminal stages and follows the same decreasing pattern as in spinal cord, standing out from the generally increased muscle circRNAs.
Confidence score:

0.1155
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

biological research
Data availability: -
Code availability: -