| Expression pattern: |
UN |
| Associated gene: |
rRNA |
| Associated microRNA: |
- |
| Biological function: |
Atheroprotection; associated with decreased oxidative stress |
| Molecular mechanism: |
Regulation of ribosomal RNA (rRNA) maturation and microRNA sponging |
| Biological pathway or process: |
oxidative phosphorylation (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
circular isoforms of ANRIL correlated with a decrease in oxidative stress |
| Description: |
In severe CAD patients, circular ANRIL (circANRIL) expression is associated with lower oxidative stress. The paper discusses circANRIL as an atheroprotective isoform, potentially acting via rRNA maturation regulation and microRNA sponging. |
| Confidence score: |
0.2995 |