| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circPVT1 is overexpressed in AML blast cells, enriched as cargo inside AML patient extracellular vesicles, and is suggested to participate in crosstalk between AML cells and the tumor microenvironment. |
| Molecular mechanism: |
extracellular vesicle cargo-mediated communication in the AML tumor microenvironment |
| Biological pathway or process: |
immune regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Digital PCR |
| Clinical significance: |
circPVT1 is more abundant inside EVs from the plasma of AML patients compared with healthy subjects and may reflect AML EV cargo features; the study suggests a potential role in AML cell-microenvironment crosstalk. |
| Description: |
This study found circPVT1 overexpression in primary AML blast cells compared with normal CD34+ cells and enrichment of circPVT1 cargo inside plasma EVs from AML patients. The authors propose that EV-associated circPVT1 may participate in communication between leukemic blasts and the tumor microenvironment, although detailed functional mechanisms were not experimentally defined. |
| Confidence score: |
0.3588 |