| Expression pattern: |
DN |
| Associated gene: |
QKI |
| Associated microRNA: |
miR-1264 |
| Biological function: |
Inhibits TNBC cell proliferation, migration, invasion, clone formation, tumor growth and lung metastasis; suppresses EMT. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1264 to regulate QKI expression, thereby repressing EMT; QKI inhibits p38 MAPK signaling. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); MAPK (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
The expression of circDDX21 showed a close association with the tumour grade, lymph node metastasis, and pathological stage of TNBC; low expression of circDDX21 indicated prolonged survival in TNBC patients. |
| Description: |
circDDX21 is down-regulated in TNBC and suppresses malignant behaviors (proliferation, migration, invasion, EMT and metastasis). Mechanistically, it acts as a ceRNA that sponges miR-1264 to relieve repression of QKI, with downstream inhibition of p38 MAPK signaling. |
| Confidence score: |
0.8498 |