circRNA basic information
circBase ID: -
Name: hsa_circ_SCMH1
Synonym: hsa‐SCMH1_0001
Host Gene: SCMH1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson's disease / PD
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ARID1A, C1orf115
Associated microRNA: hsa‐miR‐1182, hsa‐miR‐1236‐3p, hsa‐miR‐1238‐3p, hsa‐miR‐146b‐3p, hsa‐miR‐431‐5p, hsa‐miR‐432‐5p, hsa‐miR‐486‐3p, hsa‐miR‐545‐3p, hsa‐miR‐558, hsa‐miR‐607, hsa‐miR‐609, hsa‐miR‐626, hsa‐miR‐635, hsa‐miR‐1827, hsa‐miR‐874‐3p, hsa‐miR‐885‐3p, hsa‐miR‐940
Biological function: may be involved in the occurrence/pathogenesis of Parkinson's disease; lower levels associated with more severe motor symptoms
Molecular mechanism: ceRNA mechanism (predicted miRNA sponge) regulating ARID1A and C1orf115
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa‐SCMH1_0001 expression level was negatively correlated with the MDS‐UPDRS III score (potential biomarker for evaluating PD severity)
Description:

Plasma exosomal hsa-SCMH1_0001 is significantly down-regulated in Parkinson's disease patients. Lower expression correlates with worse motor symptoms (higher MDS-UPDRS III). A predicted ceRNA network suggests hsa-SCMH1_0001 may regulate ARID1A and C1orf115 via binding multiple miRNAs.
Confidence score:

0.4032
Other information
Title:

Transcriptome sequencing of circular RNA reveals the involvement of hsa-SCMH1_0001 in the pathogenesis of Parkinson's disease.

Journal: CNS neuroscience & therapeutics
Published: 2024
PubMed ID: 37664885
Study type:

combined biological and clinical study
Data availability: The datasets generated and/or analyzed during the current study are not publicly available; available from the corresponding author on reasonable request.
Code availability: -