circRNA basic information
circBase ID: hsa_circ_0000745
Name: hsa_circ_SPECC1
Synonym: circSPECC1
Host Gene: SPECC1
Genomic location(hg19): chr17:20107645-20109225:+
Genomic location(hg38): chr17:20204332-20205912:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

circSPECC1 is strongly down-regulated in spinal cord at terminal-stage ALS in SOD1G93A mice; it was not quantifiable in quadriceps, consistent with CNS-enriched expression in this study.
Confidence score:

0.1155
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

biological research
Data availability: -
Code availability: -