circRNA basic information
circBase ID: hsa_circ_0001017
Name: hsa_circ_XPO1
Synonym: circXPO1
Host Gene: XPO1
Genomic location(hg19): chr2:61749745-61761038:-
Genomic location(hg38): chr2:61522610-61533903:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps; cortex; brainstem
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DS
Associated gene: RHOB
Associated microRNA: -
Biological function: potential biomarker (suggested)
Molecular mechanism: host-gene related regulation (literature-mentioned); not mechanistically tested in this study
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Potential biomarker of ALS or muscle damage (proposed)
Description:

circXPO1 shows tissue-dependent dysregulation in ALS models (decreased in CNS, generally increased in quadriceps) and is significantly deregulated in sALS brain; it is discussed as a potential ALS biomarker.
Confidence score:

0.2995
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

combined biological and clinical study
Data availability: GSE289637
Code availability: -