circRNA basic information
circBase ID: -
Name: hsa_circ_KCNN2
Synonym: circKCNN2
Host Gene: KCNN2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain tissue; frontal cortex
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circKCNN2 is decreased in AD and FTLD-TDP43 brain samples and its levels correlate negatively with Braak scores.
Molecular mechanism: -
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Clinical Sample Validation
Clinical significance:

circKCNN2 showed altered expression in AD and FTLD-TDP43 brain tissue and correlated with Braak staging.
Description:

circKCNN2 was significantly down-regulated in sporadic and autosomal dominant AD and was also reduced in FTLD-TDP43. Its negative correlation with Braak scores links its expression to neuropathological severity.
Confidence score:

0.429
Other information
Title:

Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration.

Journal: Neurobiology of aging
Published: 2020
PubMed ID: 32335360
Study type:

clinical study
Data availability: Supplementary data; https://doi.org/10.1016/j.neurobiolaging.2020.03.017
Code availability: -