circRNA basic information
circBase ID: hsa_circ_0034880
Name: hsa_circ_TTBK2
Synonym: circTTBK2
Host Gene: TTBK2
Genomic location(hg19): chr15:43164808-43170882:-
Genomic location(hg38): chr15:42872610-42878684:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps; cortex; brainstem
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circTTBK2 is significantly down-regulated in brain samples from sporadic ALS patients versus controls, and is part of the circRNA panel showing overall CNS decrease in ALS.
Confidence score:

0.5129
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

combined biological and clinical study
Data availability: GSE289637
Code availability: -