| Expression pattern: |
DN |
| Associated gene: |
ROCK1 / Rho-associated kinase 1 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits NPC cell proliferation, cell cycle progression, migration, invasion and metastasis. |
| Molecular mechanism: |
Circular RNA_LARP4 downregulates and targets ROCK1 in NPC. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circular RNA_LARP4 could serve as a promising marker for NPC. |
| Description: |
Circular RNA_LARP4 is down-regulated in NPC tissues and cell lines. Its overexpression suppresses NPC cell proliferation, cell cycle progression, migration and invasion in vitro, at least partly through downregulation of ROCK1. The study proposes circular RNA_LARP4 as a tumor-suppressive circRNA and a potential marker for NPC. |
| Confidence score: |
0.5761 |