circRNA basic information
circBase ID: hsa_circ_0001821
Name: hsa_circ_PVT1
Synonym: -
Host Gene: PVT1
Genomic location(hg19): chr8:128902834-128903244:+
Genomic location(hg38): chr8:127890588-127890998:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumors; adjacent normal tissues; LUAD tissues; LUSC tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential oncogenic role in NSCLC progression and serves as a diagnostic biomarker for NSCLC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC curve analysis supports diagnostic potential to discriminate NSCLC from normal tissues (AUC 0.863).
Description:

hsa_circ_0001821 (circPVT1) is up-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It has diagnostic potential for NSCLC by ROC analysis and is suggested to potentially promote NSCLC progression.
Confidence score:

0.6605
Other information
Title:

RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.

Journal: Molecular cancer
Published: 2019
PubMed ID: 31484581
Study type:

combined biological and clinical study
Data availability: All the data obtained and/or analyzed during the current study were available from the corresponding authors on reasonable request.
Code availability: -