circRNA basic information
circBase ID: hsa_circ_0101463
Name: hsa_circ_METTL3
Synonym: circMETTL3
Host Gene: METTL3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: Triple negative breast cancer
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TNBC tissues; adjacent normal tissues
Cell lines:

MDA-MB-231; BT-549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: METTL3
Associated microRNA: miR-34c-3p
Biological function: inhibits proliferation; inhibits migration; inhibits invasion; inhibits tumor growth; inhibits metastasis
Molecular mechanism: circMETTL3 acts as a sponge for miR-34c-3p to up-regulate METTL3.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; In Vivo Animal Model
Clinical significance:

may be a potential prognostic biomarker and therapeutic target for TNBC
Description:

In TNBC, circMETTL3 is up-regulated and functions as a ceRNA by sponging miR-34c-3p, thereby increasing METTL3 expression. circMETTL3 over-expression suppresses TNBC cell proliferation, migration, invasion, and reduces tumor growth and lung metastasis in vivo.
Confidence score:

0.528
Other information
Title:

METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 35004298
Study type:

combined biological and clinical study
Data availability: GSE38959; TCGA
Code availability: -