circRNA basic information
circBase ID: -
Name: hsa_circ_ASPH
Synonym: circASPH(2,4)
Host Gene: ASPH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005229
MONDO name: bacterial infectious disease with sepsis
Disease details: sepsis
Disease DO ID:
 0040085
Disease MeSH ID:
 D016470
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TLR2, CPEB4, ZC3H12D
Associated microRNA: hsa-miR-6818-3p, hsa-miR-7975, hsa-miR-384, hsa-miR-670-3p
Biological function: unknown
Molecular mechanism: Putative miRNA binding (sponge) and putative RBP interactions; possible RBP-facilitated biogenesis (CPEB4/TLR2 binding to flanking introns).
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other); Hedgehog (other); immune regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Both isoforms were highly expressed at ICU admission (ICU-AD) compared with ICU discharge (ICU-DC).
Description:

circASPH(2,4) is significantly up-regulated in septic patient PBMCs at ICU admission versus ICU discharge. The study predicts it may interact with specific miRNAs and RBPs (e.g., TLR2, CPEB4, ZC3H12D), suggesting potential ceRNA/RBP-related roles, but these interactions are bioinformatically inferred rather than experimentally validated.
Confidence score:

0.6193
Other information
Title:

Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target.

Journal: Scientific reports
Published: 2025
PubMed ID: 40594478
Study type:

combined biological and clinical study
Data availability: PRJNA1191529
Code availability: -