| Expression pattern: |
UP |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
hsa-miR-23-5p |
| Biological function: |
Potential non-invasive biomarker for diagnosing periodontitis and distinguishing periodontitis from non-periodontitis. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA network and predicted interaction with RBP EIF4A3 (potential circRNA-RBP network). |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (other); immune regulation (other); Wnt/beta-catenin (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential salivary biomarker distinguishing periodontitis from non-periodontitis with AUC up to 1.0. |
| Description: |
hsa_circ_0003563 (circRUNX2) is up-regulated in saliva of periodontitis patients and shows strong diagnostic performance for distinguishing periodontitis from non-periodontitis. Bioinformatic analyses predict a circRNA-miRNA-mRNA network (including miR-23-5p) and potential interaction with the RBP EIF4A3, suggesting roles in immune response and inflammation. |
| Confidence score: |
0.559 |