circRNA basic information
circBase ID: hsa_circ_0006354
Name: hsa_circ_VAMP3
Synonym: circVAMP3 / circRNA.1_7777160_7778169
Host Gene: VAMP3
Genomic location(hg19): chr1:7837219-7838229:+
Genomic location(hg38): chr1:7777159-7778169:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015796
MONDO name: acute lung injury
Disease details: acute lung injury / ALI
Disease DO ID:
 -
Disease MeSH ID:
 D055371
Disease NCIt ID:
 C155766
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

THP-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: STING, IFN-beta
Associated microRNA: miR-580-3p
Biological function: Promotes inflammatory response in macrophage ALI model by increasing STING and IFN-beta expression.
Molecular mechanism: Acts as a ceRNA/miRNA sponge to inhibit miR-580-3p, thereby upregulating STING and promoting IFN-beta production.
Biological pathway or process:

STING/IFN (promotes); inflammation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Sanger Sequencing; Bioinformatics Analysis; Transfection
Clinical significance:

Potential biomarker and therapeutic target for ARDS.
Description:

circVAMP3 is up-regulated in an LPS-induced THP-1-derived macrophage ALI model and promotes inflammatory signaling by suppressing miR-580-3p, which increases STING and enhances IFN-beta production. The study proposes the circVAMP3/miR-580-3p/STING/IFN-beta axis as a potential therapeutic/biomarker target for ALI/ARDS.
Confidence score:

0.5202
Other information
Title:

CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-beta axis in macrophages.

Journal: PeerJ
Published: 2025
PubMed ID: 40585335
Study type:

biological research
Data availability: The raw measurements are available in the Supplementary File.
Code availability: -