| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-578 |
| Biological function: |
promotes BC cell growth, proliferation, migration and invasion |
| Molecular mechanism: |
circ_0048764 acts as a miR-578 sponge to up-regulate HMGA2 expression in BC cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Western Blot; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
high expression was significantly associated with larger tumor size, positive lymph node metastasis, and higher TNM stage of BC patients |
| Description: |
circ_0048764 is up-regulated in breast cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, it promotes BC cell growth, migration and invasion. Mechanistically, circ_0048764 sponges miR-578 to relieve repression of HMGA2, forming a circ_0048764/miR-578/HMGA2 regulatory axis. |
| Confidence score: |
0.7858 |