| Expression pattern: |
DN |
| Associated gene: |
p21 (CDKN1A) |
| Associated microRNA: |
miR-1178-3p |
| Biological function: |
inhibits cell proliferation, migration, invasion and metastasis; induces G1/S cell cycle arrest; suppresses tumor growth and metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ-ZKSCAN1 sponges miR-1178-3p to upregulate p21 (CDKN1A) |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); cell cycle (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
circ-ZKSCAN1 levels were associated with survival, tumor grade, pathological T stage and tumor recurrence; lower circ-ZKSCAN1 expression was associated with poorer overall survival and disease free survival |
| Description: |
circ-ZKSCAN1 is down-regulated in bladder cancer and acts as a tumor suppressor. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1178-3p, thereby increasing p21 (CDKN1A) and inhibiting proliferation, migration, invasion, and metastasis. Low circ-ZKSCAN1 expression is associated with recurrence and worse survival outcomes. |
| Confidence score: |
0.8191 |