| Expression pattern: |
UP |
| Associated gene: |
Snail |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, invasion and migration of liver cancer cell lines; promotes Snail expression; potential non-invasive biomarker for early diagnosis and screening of hepatocellular carcinoma |
| Molecular mechanism: |
exosomal circRNA-mediated promotion of liver cancer cell proliferation, invasion and migration, with increased expression of the tumor proliferation-related and epithelial-mesenchymal transition related protein Snail |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); EMT (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
exo_circ_0006602 can be used as a potential non-invasive biomarker for early diagnosis and screening of liver cancer; its expression correlated with HBsAg, HBeAg, liver cirrhosis and Edmondson-Steiner grade; diagnostic AUC was 0.907 and combined with AFP AUC was 0.942 |
| Description: |
Exo_circ_0006602 is up-regulated in plasma exosomes from HCC patients and shows diagnostic value superior to AFP and CEA, especially when combined with AFP. Functionally, exosomal exo_circ_0006602 promotes proliferation, migration and invasion of liver cancer cell lines and increases Snail expression. |
| Confidence score: |
0.6758 |