| Expression pattern: |
DN |
| Associated gene: |
PTEN, PI3K, Akt |
| Associated microRNA: |
miR-20b-5p |
| Biological function: |
circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells, promotes sorafenib-induced apoptosis, reduces cell migration ability, and suppresses sorafenib resistance. |
| Molecular mechanism: |
circITCH acts as an endogenous miR-20b-5p sponge to upregulate PTEN and inactivate the downstream PI3K/Akt pathway, thereby increasing sorafenib sensitivity in sorafenib-resistant HCC cells. |
| Biological pathway or process: |
PI3K/AKT (inhibits); apoptosis (promotes); migration (inhibits); drug resistance (inhibits); chemoresistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Bioinformatics Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
Low circITCH expression is closely associated with poor prognosis in HCC, while high circITCH levels are associated with favorable survival; circITCH may be a target for enhancing sorafenib sensitivity in HCC. |
| Description: |
circITCH is down-regulated in HCC tissues and cell lines, especially in sorafenib-resistant HCC cells, and low circITCH expression is associated with poorer prognosis. Functionally, circITCH overexpression enhances sorafenib sensitivity, promotes apoptosis, and suppresses migration in sorafenib-resistant HCC cells by sponging miR-20b-5p, increasing PTEN, and inhibiting PI3K/Akt signaling. |
| Confidence score: |
0.7779 |