| Expression pattern: |
UP |
| Associated gene: |
EIF4A3, MINK1 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration, invasion, and tumor growth in PTC |
| Molecular mechanism: |
EIF4A3 positively regulates circ_0092278 biogenesis/expression via binding MINK1 transcript; circ_0092278 activates PI3K/AKT/mTOR signaling |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circ_0092278 expression was associated with larger tumor size, lymphovascular invasion, and lymph node metastasis in PTC patients. |
| Description: |
circ_0092278 is up-regulated in papillary thyroid cancer and predominantly localized in the cytoplasm. It promotes PTC cell proliferation, migration, invasion and xenograft tumor growth by activating the PI3K/AKT/mTOR pathway, and is positively regulated by the RBP EIF4A3 via binding to the host transcript MINK1. |
| Confidence score: |
0.753 |