| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
miR-522-3p |
| Biological function: |
circ_0046264 acts as a tumor suppressor in NSCLC cells; its overexpression inhibits cell viability, colony formation, adhesion, migration and invasion, while its knockdown partially counteracts bufalin-mediated anti-tumor effects. |
| Molecular mechanism: |
circ_0046264 directly targets and negatively regulates miR-522-3p, mediating the anti-tumor effect of bufalin through the circ_0046264/miR-522-3p axis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
This study identifies circ_0046264 as a bufalin-responsive tumor-suppressive circRNA in NSCLC cell models. Bufalin increases circ_0046264 expression, and circ_0046264 suppresses NSCLC proliferation, adhesion, migration, invasion and xenograft tumor growth by targeting miR-522-3p. |
| Confidence score: |
0.6578 |