circRNA basic information
circBase ID: -
Name: hsa_circ_RAD18
Synonym: circRAD18
Host Gene: RAD18
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005406
MONDO name: gestational diabetes
Disease details: gestational diabetes mellitus / GDM
Disease DO ID:
 11714
Disease MeSH ID:
 D016640
Disease NCIt ID:
 C34942
Disease ICD11 ID:
 1320503631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Low plasma circRAD18 is predictive of GDM and is associated with hypertension in pregnant women.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis
Clinical significance:

Low plasma circRAD18 on the day of pregnancy confirmation distinguishes potential GDM patients from non-GDM cases and predicts GDM and hypertension.
Description:

Plasma circRAD18 levels are decreased at pregnancy confirmation in women who later develop GDM. Low plasma circRAD18 serves as a potential early biomarker predicting GDM risk and is associated with subsequent hypertension.
Confidence score:

0.4758
Other information
Title:

The application of plasma circRAD18 in the prediction of gestational diabetes mellitus (GDM) and its adverse effects.

Journal: BMC pregnancy and childbirth
Published: 2024
PubMed ID: 38658867
Study type:

clinical study
Data availability: The sets of data analyzed in the study can be obtained from the author upon request, in a reasonable manner.
Code availability: -