circRNA basic information
circBase ID: hsa_circ_0001550
Name: hsa_circ_RARS
Synonym: -
Host Gene: RARS
Genomic location(hg19): chr5:167915606-167921655:+
Genomic location(hg38): chr5:168488601-168494650:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
5672, 9256
Disease MeSH ID:
-
Disease NCIt ID:
C4978
Disease ICD11 ID:
-
Disease OMIM ID:
114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; matched tumor-adjacent normal tissues

Cell lines:

HIEC; HCT116; SW480; CACO2; SW620; HT29

In vivo animal model:

-

circRNA-disease information
Expression pattern:
UP
Associated gene: 61 mRNAs
Associated microRNA: hsa-miR-664b-3p, hsa-miR-139-5p, hsa-miR-6509-5p, hsa-miR-323a-3p, hsa-miR-370-3p, hsa-miR-181a-5p, hsa-miR-181b-5p
Biological function: Predicted to participate in CRC-associated ceRNA regulation, apoptotic processes and metabolic processes; may contribute to anti-apoptosis and tumor survival.
Molecular mechanism: Predicted ceRNA mechanism through a circRNA/miRNA/mRNA regulatory network.
Biological pathway or process:

ceRNA regulation (other); apoptosis (inhibits); other pathway/process (other)

Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis

Clinical significance:

May facilitate the finding of promising targets and biomarkers in CRC.

Description:

hsa_circ_0001550 is significantly up-regulated in CRC tissues and CRC cell lines. The study predicts that it functions within a circRNA/miRNA/mRNA regulatory network and may participate in anti-apoptotic and metabolic processes relevant to CRC progression.

Confidence score:

0.585

Other information
Title:

Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.

Journal: Journal of cellular biochemistry
Published: 2020
PubMed ID: 32115780
Study type:

combined biological and clinical study

Data availability: GSE116589; data included within the article and available from the corresponding author upon request
Code availability: -