| Expression pattern: |
UN |
| Associated gene: |
ATG7 |
| Associated microRNA: |
hsa-miR-223-3p, miR-223-3p |
| Biological function: |
circCUL3 promotes cervical cancer cell viability/proliferation, migration, invasion, EMT, autophagy and xenograft tumor growth, while suppressing apoptosis. |
| Molecular mechanism: |
circCUL3 functions as a sponge for miR-223-3p, thereby upregulating ATG7 expression and activating autophagy in cervical cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); autophagy (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
This study identifies circCUL3 as an oncogenic circRNA in cervical cancer models. circCUL3 sponges miR-223-3p to increase ATG7 expression and activate autophagy, thereby promoting proliferation, migration, invasion, EMT and tumor growth while inhibiting apoptosis. The autophagy inhibitor chloroquine partially counteracts circCUL3-driven oncogenic effects. |
| Confidence score: |
0.6542 |