| Expression pattern: |
UP |
| Associated gene: |
FBXW7, c-Myc |
| Associated microRNA: |
- |
| Biological function: |
promotes cell proliferation; accelerates tumor growth; promotes tumor progression; enhances recipient-cell proliferation via exosomal transfer |
| Molecular mechanism: |
encodes circIMP3_288aa; regulates alternative splicing of FBXW7, impairing c-Myc ubiquitination and stabilizing c-Myc; exosome-mediated paracrine signaling in tumor microenvironment |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); ubiquitination (inhibits); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Transfection; CCK8; Cell Cycle Assay; In Vivo Animal Model; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircIMP3 expression was significantly higher in PC patients and elevated expression correlated with poorer event-free survival (EFS); detectable in peripheral blood suggesting liquid biopsy potential. |
| Description: |
circIMP3 is up-regulated in prostate cancer tissues and patient peripheral blood and is associated with poorer event-free survival. It encodes the peptide circIMP3_288aa and promotes prostate cancer proliferation and xenograft tumor growth. Mechanistically, it drives alternative splicing of FBXW7, reducing c-Myc ubiquitination and stabilizing c-Myc, and it can be transferred via exosomes to enhance recipient-cell proliferation within the tumor microenvironment. |
| Confidence score: |
0.7932 |