circRNA basic information
circBase ID: hsa_circ_0008305
Name: hsa_circ_PTK2
Synonym: -
Host Gene: PTK2
Genomic location(hg19): chr8:141799572-141840625:-
Genomic location(hg38): chr8:140789473-140830526:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Significantly decreased after carboplatin and pemetrexed single treatments and completely lost under combined treatment; suggested as follow-up biomarker candidate.
Molecular mechanism: Not specified in this study.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR
Clinical significance:

May be a candidate follow-up biomarker due to decreased expression with treatment.
Description:

hsa_circ_0008305 decreases with either carboplatin or pemetrexed and becomes undetectable after combined therapy in A549 cells, supporting its candidacy as a treatment follow-up biomarker in this experimental model.
Confidence score:

0.279
Other information
Title:

Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.

Journal: Asian Pacific journal of cancer prevention : APJCP
Published: 2024
PubMed ID: 38918678
Study type:

biological research
Data availability: -
Code availability: -