circRNA basic information
circBase ID: hsa_circ_0041946
Name: hsa_circ_TP53
Synonym: -
Host Gene: TP53
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0010150
MONDO name: head and neck squamous cell carcinoma
Disease details: head and neck squamous cell carcinoma / HNSCC
Disease DO ID:
 5520
Disease MeSH ID:
 C535575
Disease NCIt ID:
 C34447
Disease ICD11 ID:
 -
Disease OMIM ID:
 275355
Species: Human
Species details: Homo sapiens
Tissue specimen:

peritumor tissue; tumor tissues
Cell lines:

FaDu
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: USP10
Associated microRNA: -
Biological function: unknown
Molecular mechanism: binds USP10 (exogenous RIP), and its expression level is increased by USP10; does not increase USP10 levels.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Clinical Sample Validation; RNA-seq
Clinical significance:

-
Description:

hsa-circ-0041946 is up-regulated in HNSCC tissues but is not correlated with prognosis. It can interact with USP10 (shown by exogenous RIP) and is stabilized by USP10, but it does not reciprocally increase USP10 levels.
Confidence score:

0.5135
Other information
Title:

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2025
PubMed ID: 40464594
Study type:

combined biological and clinical study
Data availability: -
Code availability: -