| Expression pattern: |
UP |
| Associated gene: |
USP10, p53 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration and invasion, and inhibits apoptosis in HNSCC cells; promotes xenograft tumor growth (overall, context-dependent on p53 mutation status). |
| Molecular mechanism: |
circTP53 directly binds USP10 (via intron 9 partial sequence) to mutually stabilize circTP53 and USP10, enhancing USP10 deubiquitinating activity on p53, reducing p53 polyubiquitination and stabilizing p53 protein. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ubiquitination (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Sanger Sequencing; RNase R Treatment; Northern Blot; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; ISH (In Situ Hybridization); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
High circTP53 expression correlates with worse overall survival and is associated with unfavorable clinical prognosis in HNSCC patients. |
| Description: |
circTP53 (hsa-circ-0041947) is up-regulated in HNSCC and high expression is associated with poor overall survival. It binds USP10 (via partial intron 9) and mutually stabilizes USP10, enhancing USP10-mediated deubiquitination and stabilization of p53, thereby modulating HNSCC progression in a p53-mutation-status-dependent manner. |
| Confidence score: |
0.8829 |