| Expression pattern: |
DN |
| Associated gene: |
MTMR3 |
| Associated microRNA: |
miR-99a-5p |
| Biological function: |
sensitizes GC cells to CDDP; inhibits proliferation; promotes apoptosis; reduces autophagy; suppresses cisplatin resistance |
| Molecular mechanism: |
ceRNA mechanism: circMCTP2 sponges miR-99a-5p to upregulate MTMR3, thereby inhibiting autophagy and cisplatin resistance |
| Biological pathway or process: |
chemoresistance (inhibits); proliferation (inhibits); apoptosis (promotes); autophagy (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; TUNEL; Survival Analysis; ROC Analysis; Clinical Sample Validation |
| Clinical significance: |
circMCTP2 could be a predictive biomarker for CDDP resistance in GC; high circMCTP2 expression is associated with better prognosis |
| Description: |
circMCTP2 is down-regulated in cisplatin-resistant gastric cancer cells/tissues. Functionally, circMCTP2 suppresses cisplatin resistance by inhibiting proliferation, promoting apoptosis, and reducing autophagy. Mechanistically, it acts as a ceRNA that sponges miR-99a-5p to upregulate MTMR3. |
| Confidence score: |
0.8905 |