| Expression pattern: |
UP |
| Associated gene: |
PRKACB, Ago2, VEGF |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
promotes melanoma cell proliferation, invasion, angiogenesis and tumour growth; inhibits apoptosis |
| Molecular mechanism: |
circANKRD52 functions as a ceRNA by sponging miR-141-3p to upregulate PRKACB, promoting malignant phenotypes and angiogenesis (VEGF-related). |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circANKRD52 expression was associated with poorer survival and higher tumour recurrence in patients with melanoma. |
| Description: |
circANKRD52 (hsa_circ_0026926), derived from ANKRD52, is upregulated in melanoma and mainly localized in the cytoplasm. It promotes melanoma cell proliferation, invasion, angiogenesis and in vivo tumorigenesis by sponging miR-141-3p to increase PRKACB (with associated VEGF upregulation). High circANKRD52 expression correlates with poorer survival and higher tumor recurrence. |
| Confidence score: |
0.876 |