| Expression pattern: |
UP |
| Associated gene: |
AGO1, METTL3, DGCR8, MOV10 |
| Associated microRNA: |
hsa-miR-526b-3p, Has-miR-302a-3p |
| Biological function: |
potential biomarker for diagnosis and dynamic monitoring; associated with tumor progression and metastasis-related clinicopathological features |
| Molecular mechanism: |
predicted to interact with RNA-binding proteins and may also act as a ceRNA; downstream network analyzed by bioinformatics (GO/KEGG) |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Diagnostic biomarker with high AUC; high plasma expression associated with tumor differentiation, TNM stage, T stage, lymph node metastasis, and distant metastasis; potential for dynamic monitoring |
| Description: |
circBRIP1 is up-regulated in NSCLC tissues, cell lines, and patient plasma and shows diagnostic value (ROC AUC reported). It localizes to both nucleus and cytoplasm (nucleus-predominant) and is bioinformatically predicted to function via RBP interactions and a circRNA-miRNA-mRNA ceRNA network, with enrichment suggesting immune-related involvement. |
| Confidence score: |
0.7038 |